How Does Saxenda Work?

Chemically, GLP-1 agonists like Saxenda are designed to mimic the effects of GLP-1—a hormone your body releases after you eat. Saxenda acts like GLP-1 by triggering a satiety signal in your brain and slowing down movement in your gut. The net effect is feeling more full and less hungry. The natural form of GLP-1, however, only stays in your system for a few minutes. Saxenda is broken down more slowly, allowing for a sustained effect over the course of a day.

Saxenda should be paired with lifestyle modifications due to the fact that one’s “weight set-point” (a theory that our bodies naturally want to return to a set weight, regardless of how one modifies nutrition and activity level) is very hard to change because of metabolic and hormonal processes that preserve weight, explains Dr. Mann. “Saxenda and other GLP-1 receptor agonist weight-loss medications affect those hormones, so lifestyle changes may be more effective,” she continues.

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